Antimicrobial activity of Black Cumin seeds (Nigella sativa) against multidrug resistant strains of Coagulase negative Staphylococci.

Salman, Mohd Tariq; Khan, Rahat Ali and Shukla, Indu (2008) Antimicrobial activity of Black Cumin seeds (Nigella sativa) against multidrug resistant strains of Coagulase negative Staphylococci. Hippocratic Journal of Unani Medicine, 3 (1). pp. 107-115.

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Abstract

Nigella sativa (black cumin) seed oil and methanolic extract were tested in varying dilutions against strains of Staphylococcus epidermidis and other coagulase-negative staphylococci resistant to a number of clinically used antibiotics isolated from patients attending JN Medical College Hospital, Aligarh, using disc agar diffusion technique on inoculated Muellar Hinton agar plates under standard laboratory conditions. Both the oil and extract showed remarkable dose dependent antibacterial activity against the tested strains upto a dilution of 1:50 as evident from the zones of inhibition. No cross resistance was noticed with any of the tested antibiotics. To the best of our knowledge, the activity of N. sativa against multidrug resistant clinical strains of Coagulase negative staphylococci is being reported for the first time.

EPrint Type:Article
Uncontrolled Keywords:Nigella sativa, Staphylococcus epidermidis, Coagulase negative staphylococci, Antimicrobial activity, Antibiotic resistance
Subjects:Investigative Techniques > Clinical Laboratory Techniques > Culture Techniques
Bacteria > Gram-Positive Bacteria
Biological Sciences > Pharmacology
Chemical Actions and Uses > Pharmacologic Actions > Therapeutic Uses > Anti-Infective Agents > Anti-Bacterial Agents
Chemical and Pharmacologic Phenomena > Drug Resistance
Biological Phenomena, Cell Phenomena, and Immunity > Biological Phenomena
Equipment and Supplies > Culture Media
Plants > Plants, Medicinal
ID Code:2773
Deposited By:Dr Mohd Tariq Salman
Deposited On:21 April 2008

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