Immunologic tests for the diagnosis of tuberculosis

Chaparas, Sotiros D. (1985) Immunologic tests for the diagnosis of tuberculosis. Indian Journal of Tuberculosis, 32 (1). pp. 3-18.

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Abstract

The extensive antigenic sharing between species of mycobacteria often complicates the diagnostic value of serologic tests and tests for cellular hypersensitivity in tuberculosis. Purification of antigens or the preparation of hybridoma monoclonal antibodies offer only a partial solution in that the immunologic response to Mycobacierium tuberculosis is variable so that a battery of “pure” antigens or monoclonal antibodies, highly specific for the tubercle bacillus, may be required for satisfactory sensitivity. The multi determinant nature of antigens further complicates a full solution to specificity. Although a single antigen molecule may possess epitopes specific for M. tuberculosis it may also bear nonspecific ones. The tests available today are sensitive and useful as aids in the diagnosis of tuberculosis. In many situations a high liter or a strong tuberculin reaction may provide strong indications of a tuberculous infection. However, a diagnosis must consider other criteria as well, such as, clinical symptoms, radiological findings and, especially, isolation and identification of the etiologic agent.

EPrint Type:Article
Uncontrolled Keywords:Immunologic Tests, Pulmonary Tuberculosis, Mycobacterium tuberculosis, Tuberculin, Mycobacteria, Antigens, Antibodies, Diagnosis, Etiology
Subjects:Immunologic and Biological Factors > Immunologic Factors > Antibodies
Diagnosis > Diagnostic Techniques and Procedures
Immunologic and Biological Factors > Immunologic Factors > Antigens > Antigens, Bacterial > Tuberculin
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Immunologic and Biological Factors > Immunologic Factors > Antigens > Antigens, Bacterial
Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Health Occupations > Serology
Investigative Techniques > Immunologic Techniques
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2801
Deposited By:Mrs Naina Pandita
Deposited On:10 April 2008

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