Significance of soluble antigen fluorescent antibody test in the serodiagnosis of tuberculosis
Sharma, Usha Kiran (1985) Significance of soluble antigen fluorescent antibody test in the serodiagnosis of tuberculosis. Indian Journal of Tuberculosis, 32 (2). pp. 65-80.
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SAFA test detected significant levels of antibodies to Mycobacterial Saline Extract (MSE) antigen, in new cases of pulmonary tuberculosis (bacteriologically positive and negative.) alike It was also useful in prognosis of disease process as the antibody level in 1 year treated cases showed correlation with healing process. Statistical analyses established a significant difference in the antibody response of proved cases of pulmonary and extrapulmonary tuberculosis, versus the healthy control-group). IHA test was also found to detect anti-PPD antibodies. However, the false positive and false negative reactions were found to be much higher, as compared to those obtained by SAFA test. IHA test also revealed a significant difference in the antibody response of pulmonary and extrapulmonary tuberculosis versus the healthy control group. SAFA test was found to be negative in cases of mvco-bacterioses and also it was found negative in the post-BCG vaccinated cases.
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