Treatment of long-term tuberculosis treatment failure

Khanna, B.K. (1985) Treatment of long-term tuberculosis treatment failure. Indian Journal of Tuberculosis, 32 (4). pp. 171-175.

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Abstract

15 cases of sputum positive pulmonary tuberculosis, who had failed to respond to most of the known chemotherapeutic regimens, were admitted to hospital. They were all administered en injectable (Kanamycin in 13 cases and Capreomycin in 2) along with PAS ethionamide and cycloserine in 13 cases and Rifampicin and pyrazinamicte in the other 2. One case from whom Myco-Kansasii was isolated was excluded from the study. At the end of 6 months, the injectable was stopped. The oral medication continued for subsequent 18 months in the patients’ homes (unsupervised). Except for 2 cases’, who deteriorated and 2 who died, remaining 10 cases were discharged, much improved, with negative sputum. One case had “stress’ diabetes mellitus and another loculated cmpycma. Out of 6 cases, followed up for 6 months to 2 years, after cessation of therapy, 1 died 2 years after discharge from the hospital. He was extremely irregular during domiciliary phase of treatment. Another case relapsed 6 months after stopping the drugs. This regimen though costly (Rs. 700 per annum) is worth attempting on patients who are given up as hopeless because of failure of previous treatment.

EPrint Type:Article
Uncontrolled Keywords:Pulmonary Tuberculosis, Sputum, Chemotherapy, Drug Regime, Failed Treatment, Kanamycin, Capreomycin, Ethionamide, ,Pyrazinamide, Rifampicin, Stress Diabetes Mellitus, Cycloserine, Hopitalization, PAS, Side Effects, Domiciliary Treatment
Subjects:Therapeutics > Drug Therapy
Diagnosis > Prognosis
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Pharmaceutical Preparations > Drug Combinations
Organic Chemicals > Carboxylic Acids > Hydroxy Acids > Hydroxybenzoic Acids > Salicylic Acids > Aminosalicylic Acids > p-Aminosalicylic Acid
Chemical and Pharmacologic Phenomena > Drug Tolerance
Therapeutics > Patient Care
Investigative Techniques > Drug Administration Schedule
Amino Acids, Peptides, and Proteins > Peptides > Peptides, Cyclic
Health Services Administration > Patient Care Management
Fluids and Secretions > Bodily Secretions > Sputum
Health Care Facilities, Manpower, and Services > Health Services > Community Health Services > Home Care Services
Organic Chemicals > Amines > Polyamines
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Health Care Quality, Access, and Evaluation > Quality of Health Care
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyridines
Health Services Administration > Quality of Health Care
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2842
Deposited By:Mrs Naina Pandita
Deposited On:01 May 2008

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