In vitro antimicrobial activity of Nigella sativa oil against multi-drug resistant bacteria.

Salman, Mohd Tariq; Khan, Rahat Ali and Shukla, Indu (2006) In vitro antimicrobial activity of Nigella sativa oil against multi-drug resistant bacteria. Unimed Kulliyat, II (1). pp. 8-13.

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Abstract

Nigella sativa L. essential oil was studied for antibacterial activity against various clinical isolates of bacteria resistant to a number of antibiotics, in varying concentrations by Disc Agar diffusion technique using impregnated filter paper discs on inoculated Muellar Hinton agar plates. The oil showed pronounced dose dependent antibacterial activity which was more against Gram +ve than Gram –ve bacteria. Among Gram +ve bacteria tested, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, other coagulase –ve Staphylococci and Streptococcus pyogenes were sensitive to the oil and 2 (Enterococcus faecalis, Streptococcus agalactiae) were resistant. Among Gram –ve bacteria tested, only Pseudomonas aeruginosa was sensitive to oil and rest (Acinetobacter baumannii, Citrobacter freundii, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris and Vibrio cholerae) were insensitive. Out of 147 strains tested, most of which were resistant to a number of antibiotics, 97 were inhibited by the oil.

EPrint Type:Article
Uncontrolled Keywords:Nigella sativa, Black cumin, Antimicrobial activity, Essential oil, Antibiotic resistance, Gram Negative Bacteria, Gram Positive Bacteria, Staphylococcus, Bacillus, Streptococcus, Enterococcus, Klibsiella
Subjects:Pharmaceutical Preparations > Plant Extracts
Bacteria > Gram-Positive Bacteria
Biological Sciences > Pharmacology
Chemical Actions and Uses > Pharmacologic Actions > Therapeutic Uses > Anti-Infective Agents > Anti-Bacterial Agents
Chemical and Pharmacologic Phenomena > Drug Resistance
Biological Phenomena, Cell Phenomena, and Immunity > Biological Phenomena
Complex Mixtures > Plant Preparations > Plant Oils
Bacteria > Gram-Negative Bacteria
Plants > Plant Families and Groups > Angiosperms
Lipids > Oils > Plant Oils
ID Code:2916
Deposited By:Dr Mohd Tariq Salman
Deposited On:17 June 2008

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