Use of lamotrigine in psychiatric disorders
Eken, B. (2008) Use of lamotrigine in psychiatric disorders. Anatolian Journal of Psychiatry (Anadolu Psikiyatri Dergisi), 9 (3). pp. 169-178.
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Lamotrigine is a novel anticonvulsant drug which has multiple mechanisms of action. Along with epilepsy, it has become the treatment of choice in many areas of medicine, including various psychiatric disorders and pain syndromes. In psychiatry, there are several studies reporting the efficacy of lamotrigine in the treatment of bipolar disorder, schizophrenia, cocaine dependence, post traumatic stress disorder and borderline personality disorder. In these studies, lamotrigine was seen to be well tolerated, to be an effective mood stabilizer, to be significantly more effective in schizophrenia when given as adjunctive therapy to clozapine. However it requires medical attention when combined with other antipsychotics except for clozapine due to possible iatrogenic worsening of psychiatric symptoms. Lamotrigine has been reported to have positive treatment effects for other potential clinical applications in limited number of reports. The literature related with lamotrigine use for the treatment of different psychiatric disorders has been reviewed in this paper.
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