T Wave alternans and ventricular tachyarrhythmia risk stratification: a review

Takagi, Masahiko and Yoshikawa, Junichi (2003) T Wave alternans and ventricular tachyarrhythmia risk stratification: a review. Indian Pacing and Electrophysiology Journal, 3 (2). pp. 67-74. ISSN 0972-6292

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Abstract

Sudden cardiac death (SCD) is one of the leading causes of mortality in industrialized countries. Thus, identifying patients at high risk of SCD is an important goal. T wave alternans (TWA) is a new method for identifying patients with lethal ventricular tachyarrhythmias, and is dependent on heart rate. The maximal predictive accuracy is achieved at heart rates between 100 and 120 bpm, so that TWA is usually measured during exercise, phamacological stress, or atrial pacing. It has been shown that TWA has high sensitivity and negative predictive value for predicting SCD after myocardial infarction and is also useful for predicting SCD in patients with nonischemic cardiomyopathy. Although the implantable cardioverter defibrillator (ICD) is now the primary therapy for preventing SCD, it is difficult to identify those patients who are susceptible to lethal ventricular tachyarrhythmias for primary prevention. In the prediction of SCD, TWA can be used as a screening test of appropriate patients for further electrophysiological examination and therapy.

EPrint Type:Article
Uncontrolled Keywords:T wave alternans, sudden cardiac death, ventricular tachyarrhythmia
Subjects:-Journal Repositories > Indian Pacing and Electrophysiology Journal
Cardiovascular Diseases > Heart Diseases > Heart Arrest
Cardiovascular Diseases > Heart Diseases > Arrhythmia
Pathological Conditions, Signs and Symptoms > Pathologic Processes > Death
ID Code:300
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:22 July 2005

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