A study of chronopharmacokinetics of pyrazinamide in tuberculosis patients
Kulshrestha, Sandhya (1986) A study of chronopharmacokinetics of pyrazinamide in tuberculosis patients. Indian Journal of Tuberculosis, 33 (2). pp. 66-75.
Full text available as:
The chronopharmacokinetics of pyrazinamide (PZN) was studied in 20 confirmed cases of pulmonary tuberculosis. A single fixed dose of 1.5 gm of PZN was administered at three fixed times viz. 7A.M. 11 A.M. and 7 P.M. to each patient. PZN contents were estimated in the blood and PZN and Pyrazinoic acid (PZA) contents in the urine and various pharmacokinetic parameters viz: Cmax, Tmax, t 1/2, AUC, Yd, Clp, Clr, duration of cone. >25 ug/ml, total excretion of PZN and PZA were evaluated. Wide intermdevidual fluctuations were noticed in the parameters and the differences observed in most of the results were not statistically significant. However. Tmax (Time to peak cone.) when the drug was administered at 7 P.M. was delayed and was found to be highly significant, indicating slower rate of absorption when the drug was administered at night. The area under serum cone, time curve and duration of minimum effective cone. (>25 ug-/ml) was also found to be greater although this was not statistically significant). It is hypothesised (hat. probably, the extent of the total absorption of PZN from gastrointestinal tract was more when drug was administered at night. However, since this study is based on a small group of patients of the same ethnic class, a study on large number of patients from different ethnic would he required to substantiate the present finding,
Archive Staff Only: edit this record