A study of chronopharmacokinetics of pyrazinamide in tuberculosis patients

Kulshrestha, Sandhya (1986) A study of chronopharmacokinetics of pyrazinamide in tuberculosis patients. Indian Journal of Tuberculosis, 33 (2). pp. 66-75.

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Abstract

The chronopharmacokinetics of pyrazinamide (PZN) was studied in 20 confirmed cases of pulmonary tuberculosis. A single fixed dose of 1.5 gm of PZN was administered at three fixed times viz. 7A.M. 11 A.M. and 7 P.M. to each patient. PZN contents were estimated in the blood and PZN and Pyrazinoic acid (PZA) contents in the urine and various pharmacokinetic parameters viz: Cmax, Tmax, t 1/2, AUC, Yd, Clp, Clr, duration of cone. >25 ug/ml, total excretion of PZN and PZA were evaluated. Wide intermdevidual fluctuations were noticed in the parameters and the differences observed in most of the results were not statistically significant. However. Tmax (Time to peak cone.) when the drug was administered at 7 P.M. was delayed and was found to be highly significant, indicating slower rate of absorption when the drug was administered at night. The area under serum cone, time curve and duration of minimum effective cone. (>25 ug-/ml) was also found to be greater although this was not statistically significant). It is hypothesised (hat. probably, the extent of the total absorption of PZN from gastrointestinal tract was more when drug was administered at night. However, since this study is based on a small group of patients of the same ethnic class, a study on large number of patients from different ethnic would he required to substantiate the present finding,

EPrint Type:Article
Uncontrolled Keywords:Chronopharmacokinetics, Pyrazinamide, Pulmonary Tuberculosis, Patients, Pyrazionic Acid, Urine, Blood, Pharmacokinetics, Tmax, Time to Peak Cone
Subjects:Therapeutics > Chronotherapy
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Biochemical Phenomena, Metabolism, and Nutrition > Metabolism
Physiological Processes > Chronobiology
Chemical and Pharmacologic Phenomena > Biopharmaceutics
Health Care Quality, Access, and Evaluation > Quality of Health Care > Health Care Evaluation Mechanisms > Statistics > Probability
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:3002
Deposited By:Mrs Naina Pandita
Deposited On:22 August 2008

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