Choice of sample size in short-course chemotherapy trials of tuberculosis

Satagopan, M.C. and Radhakrishna, S. (1986) Choice of sample size in short-course chemotherapy trials of tuberculosis. Indian Journal of Tuberculosis, 33 (2). pp. 77-81.

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Abstract

Two approaches to computing sample size in clinical trials of short-course chemotherapy are described. One pertains to the conventional comparison situation, and it is concluded that about 1.50-200 patients with full follow-up are required on each regimen. The second approach examines whether a regimen under study is "sufficiently highly effective" for use in the programme, and in this situation about 100-125 patients with full follow-up arc necessary. A review of published reports indicates that the sample sizes employed are usually inadequate.

EPrint Type:Article
Uncontrolled Keywords:Short-course Chemotherapy, Pulmonary Tuberculosis, Clinical Trials, Patients, Sample Size
Subjects:Information Science > Data Collection
Therapeutics > Drug Therapy
Health Care Quality, Access, and Evaluation > Quality of Health Care > Health Care Evaluation Mechanisms > Data Collection
Environment and Public Health > Public Health > Epidemiologic Methods > Data Collection > Health Surveys
Investigative Techniques > Epidemiologic Methods
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Investigative Techniques > Epidemiologic Methods > Data Collection
Persons > Patients
Environment and Public Health > Public Health > Epidemiologic Methods > Data Collection
Environment and Public Health > Public Health > Epidemiologic Methods
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:3005
Deposited By:Mrs Naina Pandita
Deposited On:25 August 2008

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