Choice of sample size in short-course chemotherapy trials of tuberculosis
Satagopan, M.C. and Radhakrishna, S. (1986) Choice of sample size in short-course chemotherapy trials of tuberculosis. Indian Journal of Tuberculosis, 33 (2). pp. 77-81.
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Two approaches to computing sample size in clinical trials of short-course chemotherapy are described. One pertains to the conventional comparison situation, and it is concluded that about 1.50-200 patients with full follow-up are required on each regimen. The second approach examines whether a regimen under study is "sufficiently highly effective" for use in the programme, and in this situation about 100-125 patients with full follow-up arc necessary. A review of published reports indicates that the sample sizes employed are usually inadequate.
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