Influence of rifampicin on immunosuppression as measured by DNCB skin test
Sharma, T.N.; Jain, N.K.; Sharma, R.C.; Kala, D.K.; Agnihotri, S.P.; Purohit, S.D. and Jenaw, R.K. (1986) Influence of rifampicin on immunosuppression as measured by DNCB skin test. Indian Journal of Tuberculosis, 33 (3). pp. 117-120.
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Skin sensitization with DNCB was carried out in. 40 healthy controls. Forty freshly diagnosed, untreated patients of pulmonary tuberculosis, 40 patients of pulmonary tuberculosis treated with rifampicin containing regimens and 40 patients treated with non-rifampicin regimens by Catalona’s Method. All the healthy controls could be sensitized to DNCB and the degree of sensitization was 44- in majority of them. In contrast 65 per cent of “untreated”, 30 per cent of “Rifampicin-treated” and 35 per cent of “Non-Rifampicin-treated” patients of pulmonary tuberculosis failed to develop sensitisation to DNCB and only 2 showed a 4+-response. Rifaimpicin in therapeutic dosage did not show any effect on cell mediated immunity (CMJ) as shown by DNCB skin-sensitization
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