Influence of rifampicin on immunosuppression as measured by DNCB skin test

Sharma, T.N.; Jain, N.K.; Sharma, R.C.; Kala, D.K.; Agnihotri, S.P.; Purohit, S.D. and Jenaw, R.K. (1986) Influence of rifampicin on immunosuppression as measured by DNCB skin test. Indian Journal of Tuberculosis, 33 (3). pp. 117-120.

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Skin sensitization with DNCB was carried out in. 40 healthy controls. Forty freshly diagnosed, untreated patients of pulmonary tuberculosis, 40 patients of pulmonary tuberculosis treated with rifampicin containing regimens and 40 patients treated with non-rifampicin regimens by Catalona’s Method. All the healthy controls could be sensitized to DNCB and the degree of sensitization was 44- in majority of them. In contrast 65 per cent of “untreated”, 30 per cent of “Rifampicin-treated” and 35 per cent of “Non-Rifampicin-treated” patients of pulmonary tuberculosis failed to develop sensitisation to DNCB and only 2 showed a 4+-response. Rifaimpicin in therapeutic dosage did not show any effect on cell mediated immunity (CMJ) as shown by DNCB skin-sensitization

EPrint Type:Article
Uncontrolled Keywords:DNCB, Skin Sensitization, Rifampicin, 1-chloro 2, 4-dinitrochlorobenzene, Pulmonary Tuberculosis, Child, Adult, Drug Therapy, Catalona’s Method
Subjects:Persons > Age Groups
Organic Chemicals > Nitro Compounds > Nitrobenzenes
Therapeutics > Drug Therapy
Genetic Phenomena > Sex Ratio
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Immunologic Diseases > Hypersensitivity > Drug Hypersensitivity
Organic Chemicals > Hydrocarbons > Hydrocarbons, Halogenated
Fluids and Secretions > Bodily Secretions > Sputum
Integumentary System > Skin
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Investigative Techniques > Toxicity Tests
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
Pathological Conditions, Signs and Symptoms > Signs and Symptoms > Skin Manifestations
Immunologic and Biological Factors > Immunologic Factors > Antigens
-Journal Repositories > Indian Journal of Tuberculosis
Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic
ID Code:3011
Deposited By:Mrs Naina Pandita
Deposited On:27 August 2008

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