Atrial remodeling: evolving concepts

Biffi, Mauro and Boriani, Giuseppe (2003) Atrial remodeling: evolving concepts. Indian Pacing and Electrophysiology Journal, 3 (2). pp. 81-87. ISSN 0972-6292

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The term "Electsiological remodelingrophy" defines the changes of atrial electrophysiologic properties taking place in atrial myocites during atrial fibrillation and/or following periods of sustained atrial fibrillation (AF). Early research was prompted by clinical observations: many patients were seen to get through increasingly frequent and longer paroxisms of AF to persistent AF, until chronic AF eventually ensued, without significant changes of underlying heart disease. Indeed, clinical electrophysiology investigations reported peculiar differences between AF patients and patients without atrial arrhythmias. It was felt that the electrophysiologic milieu was the cause of AF 1,2, until a change of perspective occurred in the early 90's, thanks to experimental research. In his pioneering work, Wijffels kept goats fibrillating by an implanted device, while measuring atrial refractoriness and its rate adaptation as spontaneous restoration of sinus rhythm occurred. He found that, after several self terminating short bouts of AF, the arrhythmia became considerably longer until a duration of days or weeks was reached. The electrophysiologic companionship of AF pattern transformation consisted of significant shortening of atrial fibrillation cycle, which was paralleled by shortening of atrial ERP and loss of ERP adaptation to heart rate: either flat (no change with shortening cycle length) or inverted (paradoxical shorter ERP at longer cycle length) ERP relationships to cycle length were observed.

EPrint Type:Article
Uncontrolled Keywords:Atrial Remodeling, "Electsiological remodeling, Arrhythmias
Subjects:Circulatory and Respiratory Physiology > Cardiovascular Physiology > Cardiovascular Physiologic Phenomena > Hemodynamic Phenomena > Heart Rate
Cardiovascular Diseases > Heart Diseases > Arrhythmia
ID Code:302
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:22 July 2005

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