Hypoxia inducible factor-1α (HIF-1 α) and its role in tumour progression to malignancy

Sharma, Gaurav Mrinal (2008) Hypoxia inducible factor-1α (HIF-1 α) and its role in tumour progression to malignancy. Online Journal Of Health And Allied Sciences, 7 (2). ISSN 0972-5997

Full text available as:

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
145 Kb

Abstract

Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for over expression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer.

EPrint Type:	Article
Uncontrolled Keywords:	HIF, HIF-1α, Hypoxia, Malignancy, Cancer, Cancer Therapy, Hypoxic Tissue, Gliomas
Subjects:	Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins Pathological Conditions, Signs and Symptoms > Pathologic Processes > Disease Attributes Pathological Conditions, Signs and Symptoms > Signs and Symptoms > Signs and Symptoms, Respiratory Neoplasms > Neoplasms by Histologic Type > Neoplasms, Glandular and Epithelial -Journal Repositories > Online Journal of Health and Allied Sciences Neoplasms > Neoplasms by Histologic Type > Neoplasms, Germ Cell and Embryonal Biochemical Phenomena, Metabolism, and Nutrition > Biochemical Phenomena Antineoplastic and Immunosuppressive Agents > Antineoplastic Agents Neoplasms > Neoplasms by Histologic Type > Neoplasms, Nerve Tissue
ID Code:	3047
Deposited By:	Dr Srinivas Kakkilaya
Deposited On:	08 September 2008

Archive Staff Only: edit this record