Hypoxia inducible factor-1α (HIF-1 α) and its role in tumour progression to malignancy
Sharma, Gaurav Mrinal (2008) Hypoxia inducible factor-1α (HIF-1 α) and its role in tumour progression to malignancy. Online Journal Of Health And Allied Sciences, 7 (2). ISSN 0972-5997
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Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for over expression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer.
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