Kanamycin plus rifampicin plus ethambutol in the retreatment of patients with tubercle bacilli resistant to isoniazid and streptomycin

Balasubramanian, Rani; Alexander, C.; Prabhakar, R.; Paramasivan, C.N.; Rajaram, K.; Somasundaram, P.R. and Thyagarajan, K. (1987) Kanamycin plus rifampicin plus ethambutol in the retreatment of patients with tubercle bacilli resistant to isoniazid and streptomycin. Indian Journal of Tuberculosis, 34 (1). pp. 12-16.

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Abstract

A total of 70 patients, who had failed on primary chemotherapy and had organisms resistant to streptomycin and isoniazid but sensitive to rifampicin, were prescribed rifampicin plus ethambutol thrice weekly for 12 months, supplemented by kanamycin thrice weekly in the first 3 months. In all, 57 patients were included in the main analyses; a high proportion had extensive cavitated radiographic disease and moderately or heavily positive sputum smears. Sputum conversion was very rapid, 65 % being culture negative by 2 months and 93% by 4 months. A favourable response was obtained in 52 (91 %). The incidence of possible adverse reactions was low, 5 (7 %) requiring a modification of chemotherapy. None of 33 patients followed up for a 4-year period had a relapse.

EPrint Type:Article
Uncontrolled Keywords:Pulmonary Tuberculosis, Patients, Rifampcin, Isoniazid, Cavitated Radiographic Disease, Kanamycin, Ethambutol, Relapse, Treatment Regimen, Drug Resistance, Chemotherapy, Sputum Smears, Microscopy, Streptomycin
Subjects:Fluids and Secretions > Bodily Secretions > Sputum
Chemical and Pharmacologic Phenomena > Drug Resistance
Organic Chemicals > Hydrazines > Isoniazid
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Investigative Techniques > Microscopy
Organic Chemicals > Amines > Polyamines
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:3076
Deposited By:Mrs Naina Pandita
Deposited On:16 September 2008

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