Serum adenosine deaminase (ADA) in differential diagnosis of pulmonary tuberculosis and no tubercular respiratory diseases

Jhamaria, J.H.; Jenaw, R.K.; Luhda, S.K.; Mathur, D.K.; Parihar, H.L. and Sharma, S.K. (1988) Serum adenosine deaminase (ADA) in differential diagnosis of pulmonary tuberculosis and no tubercular respiratory diseases. Indian Journal of Tuberculosis, 35 (1). pp. 25-27.

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Abstract

Serum adenosine deaminase (ADA) levels were determined in 20 healthy controls, 102 cases of pulmonary tuberculosis, 20 cases of suppurative lung diseases (Lung abscess and bronchiectasis 10 each) and 18 cases of malignancy lung. The mean serum levels of ADA in healthy controls were 10.09 (+2.99) units/litre, in pulmonary tuberculosis 42.47 (± 3 34), suppurative Jung diseases 26.66 (± 1.63) and in malignancy lung 24.02 (± 1.35) units/litre. The mean serum ADA levels were higher in all the three groups of patients as compared to healthy controls. The difference in mean serum levels of ADA between pulmonary tuberculosis and non-lubercular lung diseases (suppurative lung diseases & malignancy lung) was also statistically signifi-cant. Specificity (100%) and sensitivity (98%,) of this test for tuberculosis is high with a cut-off limit of 33 units/litre.

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