The value of pyrazinamide in second phase of short course chemotherapy of pulmonary tuberculosis: an assessment

Rajasekaran, S.; Parmasivam, A.; Sujatha, Kumari and Palanisami, S. (1988) The value of pyrazinamide in second phase of short course chemotherapy of pulmonary tuberculosis: an assessment. Indian Journal of Tuberculosis, 35 (2). pp. 76-79.

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A clinical trial of two short course chemotherapy regimens was undertaken to evaluate the efficacy of pyrazinamide administration in second phase after the one month initial intensive phase. The two regimens were 1 S7H7K7Z7 + 5 H2R2Z2 and 1 S7H,R7Z7 + 5 H2R2. 74.6%. of 150 patients in the former regimen and 73.9% of 153 patients in the latter completed the stipulated treatment Sputum conversion by culture was attained in 98.2% and 92.9% of patients respectively at the end of two months treatment. Relapse rates were 3-92% and 3.12% respectively at the end of one year follow up and the difference was not significant. Thus, pyrazinamide did not contribute any additional benefit in second phase of short course chemotherapy. It is suggested that the initial daily intensive phase of S.C.C., containing pyrazinamide, might be shortened to a period of one month only instead of the conventional two months duration, without compromising its efficacy.

EPrint Type:Article
Uncontrolled Keywords:Pyranizamide, Pulmonary Tuberculosis, Patients, Chemotherapy, Short Course Chemotherapy, Relapse, Streptomycin, Isoniazid, Rifampicin, Drug Toxicity
Subjects:Disorders of Environmental Origin > Poisoning > Drug Toxicity
Pathological Conditions, Signs and Symptoms > Pathologic Processes > Disease Attributes
Organic Chemicals > Hydrazines > Isoniazid
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:3139
Deposited By:Mrs Naina Pandita
Deposited On:07 November 2008

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