Cell mediated immune response in South Indian pulmonary tuberculosis patients

Paranjape, R.S.; Ravoof, A.; Acharyulu, G.S.; Krishnamurthy, P.V.; Tripathy, S.P.; Prabhakar, R. and Narayanan, P.R. (1988) Cell mediated immune response in South Indian pulmonary tuberculosis patients. Indian Journal of Tuberculosis, 35 (4). pp. 163-170.

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Ninety-two untreated pulmonary tuberculosis (TB) patients and sixty two non-tuberculous (non-TB) controls drawn from the same socioeconomic strata were studied for their delayed hypersensitivity (DH), cell mediated immunity (CMl) and bacillary-load. There was no correlation between baciliary load and response in parameters of CM[, namely, lymphocyte transformation test (LTT) and leukocytes migration inhibition test (LMI). Migration Index (MI) in LMI did not correlate with DH in TB patients. There was no significant difference in the mean values of MI between TB and non-TB control patients. Response of lymphocytes to mitogens and percentage of T-rosetting cells also did not differ between TB and non-TB control patients, On the contrary, differences were found in the two groups of patients with regard to lymphocyte response to PPD antigen and mean B-cell percentage. While, among non-TB patients, high Mantoux reactors had significantly higher LTT response to PPD compared to low Mantoux reactors; no such difference was observed among TB patients. The mean B-Cell percentage was significantly higher in TB patients than in non-TB controls. The relevance of these differences in relation to tuberculosis in discussed.

EPrint Type:Article
Uncontrolled Keywords:Cell Mediated Immunity, Hypersensitivity, Pulmonary Tuberculosis, Patients, South India, Lymphocytes, Leukocytes, Mantoux, Mitogens
Subjects:Cells > Blood Cells
Diagnosis > Diagnostic Techniques and Procedures
Immunologic and Biological Factors > Immunologic Factors > Antigens > Antigens, Bacterial
Immunologic Diseases > Hypersensitivity
Biological Phenomena, Cell Phenomena, and Immunity > Immunity
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Therapeutics > Biological Therapy > Immunotherapy > Immunization
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
Immunologic and Biological Factors > Immunologic Factors > Antigens
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:3188
Deposited By:Mrs Naina Pandita
Deposited On:23 December 2008

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