A study of humoral immune response in tuberculosis

Rehman, S.F.; Vasudev, N.D.; Ingole, D.L.; Wagner, S. and Mauch, H. (1988) A study of humoral immune response in tuberculosis. Indian Journal of Tuberculosis, 35 (4). pp. 171-175.

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Humoral immune response was assessed in 75 cases of pulmonary tuberculosis and 94 controls, by an assay of IgG antibodies to the three different antigens derived from Ayoama B strain of Mycobacterium tuberculosis using ELISA. Ten patients showed low antibody activity to all the three antigens. However, the total IgG levels of these ten patients were significantly higher than the mean total IgG levels of the healthy controls , thereby ruling out a generalised immune suppression in these patients. Six out of the eight patients with lower antibody activity gave a strongly positive skin test. These findings suggest that the phenomenon of humoral immune suppression seen in a proportion of tuberculosis patients is to the specific mycobacterial antigens only.

EPrint Type:Article
Uncontrolled Keywords:Mycobacterium tuberculosis, ELISA, Humoral Immune Response, Antibody, Immune Suppression, Mycobacterial Antigens
Subjects:Immunologic and Biological Factors > Immunologic Factors > Antibodies
Hemic and Immune Systems > Immune System
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
Immunologic and Biological Factors > Immunologic Factors > Antigens
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:3189
Deposited By:Mrs Naina Pandita
Deposited On:24 December 2008

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