A study of humoral immune response in tuberculosis
Rehman, S.F.; Vasudev, N.D.; Ingole, D.L.; Wagner, S. and Mauch, H. (1988) A study of humoral immune response in tuberculosis. Indian Journal of Tuberculosis, 35 (4). pp. 171-175.
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Humoral immune response was assessed in 75 cases of pulmonary tuberculosis and 94 controls, by an assay of IgG antibodies to the three different antigens derived from Ayoama B strain of Mycobacterium tuberculosis using ELISA. Ten patients showed low antibody activity to all the three antigens. However, the total IgG levels of these ten patients were significantly higher than the mean total IgG levels of the healthy controls , thereby ruling out a generalised immune suppression in these patients. Six out of the eight patients with lower antibody activity gave a strongly positive skin test. These findings suggest that the phenomenon of humoral immune suppression seen in a proportion of tuberculosis patients is to the specific mycobacterial antigens only.
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