Field trial of short term intermittent chemotherapy of patients with pulmonary tuberculosis in Wardha district
Nayar, S.; Narang, P.; Tyagi, N.K.; Jajco, U.; Dhagn, V.R. and Bharambe, M. (1988) Field trial of short term intermittent chemotherapy of patients with pulmonary tuberculosis in Wardha district. Indian Journal of Tuberculosis, 35 (4). pp. 176-182.
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Short course intermittent chemotherapy regimens for pulmonary tuberculosis were given a field trial from February 1982 to June 1986 in district Wardha, Maharashtra The symptomatic were picked up by door to door survey and newly detected cases who were culture positive were put on treatment. The regimens for the urban patients were 2SaH2R2Z2/4S2H2 (NUI) and in half of the randomly selected patients the regimen was extended by 2S2H2 (NU2). For the rural population, the regimen was 2FI2R2Z2/4H2R2 (NR1) followed by further 2H2,R2; (NR2) in the half of the patients selected randomly. Under this field trial a total of 112 patients received the regimen NU1, The percentage of patients who become sputum negative at 15 days was 44.6%, at 60 days 54.5% and at the end of treatment i.e. 180 days, 69.6%. The extension of treatment by two months (NU2) in 61 subjects did not improve the efficacy but one bacteriological failure became negative. In the regimen NR1, 217 patients were given treatment and at 15 days the sputum negativity was 57.9%, at 60 days, 63.5%, and at the end of treatment, i.e. 180 days, 76.0%. In 140 patients the regimen NR1 was extended by two months (NR2) but there was no improvement in the negativity rate. The efficacy of the regimens, when calculated in patients who had consumed 80% or more than 80% doses by the end of the treatment was 94.8% in NU1 and 97.5% in NR1. The defaulter rate in regimen NU1 was 26.8% and in NR1 22.1%. In both (he regimens it was maximum in the first two months. The relapse rates were 0%, 0.27%, 0.97% and 3.19% in regimens NUI, NU2, NR1 and NR2 respectively.
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