Racial under-representation in clinical trials: consequence, myth, and proposition

Ojha, R.P.; Thertulien, R. and Fischbach, L.A. (2008) Racial under-representation in clinical trials: consequence, myth, and proposition. Epidemiologic Focus, 1 (1). e2. ISSN 1944-3307

Full text available as:

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
108 Kb


The historical under-representation of Blacks in clinical trials is well-documented. The ethical ramifications of racial under-representation in clinical trials are exacerbated by the epidemiologic and clinical consequences. For example, persistent under-representation undermines generalizability and challenges inferences regarding treatment safety and efficacy for minority races. The potential for such consequences warrants greater racial diversity in clinical trials. However, investigators have assumed that recruiting Blacks for clinical trials is hampered by unwillingness to participate. Recent reports indicate that the perception of unwillingness may be unjustified. An often overlooked aspect is that conventional recruitment strategies may be ineffective for recruiting racial minorities. Public health professionals from all disciplines have the collective capacity to improve racial diversity in clinical trials primarily because of access to minority communities. Public health professionals could facilitate an effort to encourage collaboration between trial centers and community health clinics in predominantly minority settings.

EPrint Type:Article
Uncontrolled Keywords:Racial Under-Representation, Clinical Trials, Public Health, Ethics, Community Health Clinics
Subjects:-Journal Repositories > Epidemiologic Focus
Behavior and Behavior Mechanisms > Psychology, Social
Persons > Research Subjects
Health Care Facilities, Manpower, and Services > Health Services > Community Health Services
Persons > Population Groups
Environment and Public Health > Public Health
Investigative Techniques > Epidemiologic Methods
Health Care Quality, Access, and Evaluation > Quality of Health Care
Health Care Quality, Access, and Evaluation > Ethics
Health Services Administration > Quality of Health Care
Social Sciences > Sociology
Environment and Public Health > Public Health > Epidemiologic Methods
ID Code:3198
Deposited By:Epidemiologic Focus
Deposited On:13 January 2009

Archive Staff Only: edit this record