Immunodiagnosis of tuberculosis: problems, progress and future projections
Agarwal, Alka and Moudgil, K.D. (1989) Immunodiagnosis of tuberculosis: problems, progress and future projections. Indian Journal of Tuberculosis, 36 (1). pp. 3-14.
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Early diagnosis of active cases of pulmonary tuberculosis is essential for initiating prompt treatment and containment of infection. The routinely used tests for diagnosis of tuberculosis are cumbersome and time consuming besides being less sensitive and/or specific. Over the past, several years, attempts have been made to develop simple, sensitive and specific immunoassays for serodiagnosis of tuberculosis. These methods are based on detection of antigen, antibody or circulating immune complexes. The merits and limitation of these method have been reviewed. The emergence of new technologies, e.g. hybridoma technology and recombinant DNA technology, has provided a new thrust 10 the development of immunoassays. The present state of the art relating to techniques with reference to immunodiagnosis of tuberculosis is presented.
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