Effect of fish oil on lipopolysaccharide-induced hydroxyapatite loss in rat alveolar bone: a preliminary study

Indahyani, Didin E.; Santoso, A.L. Supartinah; Totok, Utoro; Soesatyo, Marsetyawan H.N.E. and Sosroseno, Wihaskoro (2009) Effect of fish oil on lipopolysaccharide-induced hydroxyapatite loss in rat alveolar bone: a preliminary study. Online Journal of Health And Allied Sciences, 7 (4). ISSN 0972-5997

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Abstract

Dietary fish oil has been shown to inhibit bone resorption and, therefore, the aim of the present study was to test the hypothesis that fish oil alters lipopolysaccharide (LPS)-induced hydroxyapatite loss in rat alveolar bone. Rats were divided into four groups. The animals injected with saline or Escherichia coli-derived LPS into the maxillary alveolar mucosa on the buccoapical site of the molar region daily for 8 days were served as a negative or positive control, respectively. Other groups of animals were injected with LPS and orally treated with fish oil at the same day with or after LPS injection. The results of the present study showed that the hydroxyapatite contents of alveolar bone in rats treated with fish oil at the same day with or before LPS injection were significantly higher than those in rats injected with LPS alone, but still lower than those in untreated animals. Therefore, the present study suggests that oral treatment with fish oil may reduce LPS-induced hydroxyapatite loss in rat alveolar bone

EPrint Type:Article
Uncontrolled Keywords:Alveolar, Bone, Fish Oil, Hydroxyapatite, Rat, Bones, LPS Injection, Lipopolysaccharide-Induced Hydroxyapatite
Subjects:Lipids > Lipopolysaccharides
Lipids > Oils > Fish Oils
Musculoskeletal Diseases > Bone Diseases
Musculoskeletal Diseases > Bone Diseases > Bone Resorption
Animals > Chordata > Vertebrates > Mammals > Rodentia > Muridae > Rats
-Journal Repositories > Online Journal of Health and Allied Sciences
Musculoskeletal System > Skeleton > Bone and Bones
Stomatognathic Diseases > Mouth Diseases > Periodontal Diseases
ID Code:3235
Deposited By:Dr Srinivas Kakkilaya
Deposited On:13 March 2009

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