Determination of the acetylator phenotype employing concentrations of isoniazid in saliva
Kailasam, S.; Fatima, R.; Naryana, A.S.L. and Raghupati Sarma, G. (1989) Determination of the acetylator phenotype employing concentrations of isoniazid in saliva. Indian Journal of Tuberculosis, 36 (3). pp. 151-155.
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A simple method for classifying subjects as slow or rapid acetylators of isoniazid based on the concentration of isoniazid in saliva has been described. A test dose of 100 mg of isoniazid, irrespective of body-weight, was administered orally to 150 adult patients with pulmonary tuberculosis (during or just after completion of their treatment), and isoniazid concentrations in saliva were determined at hourly intervals from 2 to 5 hours. The distribution of the concentrations was bimodal at each hour. The test based on the 5-hour collection is recommended for the excellent discrimination between slow and rapid acetylators. The criterion for a rapid acetylator with this collection was taken to be a concentration of isoniazid < 0.4 μg/ml, and based on this criterion, 86 (57%) of the 150 pa-tients were classified as slow acetylators and 64 (43%) as rapid acetylators. This classifica-tion is in excellent agreement (97%) with that based on a standard method,
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