Hepatotoxicity with isoniazid and rifampicin combination during treatment of tuberculosis

Ramesh, R.; Jindal, S.K.; Malik, S.K. and Mehta, S. (1989) Hepatotoxicity with isoniazid and rifampicin combination during treatment of tuberculosis. Indian Journal of Tuberculosis, 36 (3). pp. 157-159.

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Abstract

Frequency of hepatitis and the possible risk factors were assessed in 50 patients of tuberculosis administered both Isoniazid and Rifampicin in combination. Four patients developed overt hepatitis while 6 others had significantly elevated hepatic enzymes. Complete recovery was observed within 2 weeks of drug withdrawal in those who had overt jaundice. The mean Hb and serum albumin were significantly tower while mean ESR and serum gamma globulins were significantly higher in those who developed hepatitis. The patients with hepatitis had more advanced disease.

EPrint Type:	Article
Uncontrolled Keywords:	Isoniazid, Tuberculosis, Pulmonary Tuberculosis, Hepatitis, ESR, Hb, Rifampicin, Hepatotoxicity, Serum Albumin
Subjects:	Disorders of Environmental Origin > Poisoning > Drug Toxicity Organic Chemicals > Hydrazines > Isoniazid Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary Disorders of Environmental Origin > Poisoning > Hepatitis, Toxic Pharmaceutical Preparations > Drug Combinations Amino Acids, Peptides, and Proteins > Proteins > Globulins Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary Amino Acids, Peptides, and Proteins > Proteins > Albumins -Journal Repositories > Indian Journal of Tuberculosis Diagnosis > Laboratory Techniques and Procedures
ID Code:	3262
Deposited By:	Mrs Naina Pandita
Deposited On:	08 June 2009

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