Hepatotoxicity with isoniazid and rifampicin combination during treatment of tuberculosis
Ramesh, R.; Jindal, S.K.; Malik, S.K. and Mehta, S. (1989) Hepatotoxicity with isoniazid and rifampicin combination during treatment of tuberculosis. Indian Journal of Tuberculosis, 36 (3). pp. 157-159.
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Frequency of hepatitis and the possible risk factors were assessed in 50 patients of tuberculosis administered both Isoniazid and Rifampicin in combination. Four patients developed overt hepatitis while 6 others had significantly elevated hepatic enzymes. Complete recovery was observed within 2 weeks of drug withdrawal in those who had overt jaundice. The mean Hb and serum albumin were significantly tower while mean ESR and serum gamma globulins were significantly higher in those who developed hepatitis. The patients with hepatitis had more advanced disease.
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