Prognostic significance of circulating immune complexes in pulmonary tuberculosis

Rattan, Ashok; Gupta, Alok Deep; Maheshwari, Navneet; Prasad, Maheshwar and Bal, Ashok (1989) Prognostic significance of circulating immune complexes in pulmonary tuberculosis. Indian Journal of Tuberculosis, 36 (3). pp. 167-169.

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Abstract

Circulating immune complexes (CIC) were quantitated at initiation and after three and six monthsmonths of chemotherapy in 74 patients with smear positive pulmonary tuberculosis and in 40 age and sex matched healthy controls. At start, CIC were present in 47 (53.5%) patients and 2(5.0%) healthy controls, a significant difference. Based on clinical and radiological data, patients were classified into four groups ranging from reactives to unreactives (RR, RI, UI and UU). CIC were present in 6 out of 13 patients in the RR group, 17 out of 24 RI patients in RI group 23 out of 26 in UI group and all 11 in UU group at the initiation of therapy. After three months of chemotherapy, CIC could be detected in only 13 patients: 2, 6 and 5 in RR, RI and UI groups respectively. After 6 months of therapy, CIC could not be detected in any of the patients and all patients were also smear negative at this time.

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