The pattern of IgG and IgM antibody response of leprosy patients of antigens of M. tuberculosis (H37Rv) using enzyme immunoassay

Agarwal, Alka and Moudgil, K.D. (1989) The pattern of IgG and IgM antibody response of leprosy patients of antigens of M. tuberculosis (H37Rv) using enzyme immunoassay. Indian Journal of Tuberculosis, 36 (3). pp. 177-180.

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Abstract

The IgG and IgM reactivity of sera from lepromatous (LL) and tuberculoid (TT) leprosy patients was analysed by enzyme immunoassays (EIAs) based on three different antigens of M. tuberculosis (H^ Rv) i.e. sonicate supernatant (SS), purified protein derivative (PPD) and intact cells (1C). The predominant response of LL and TT sera with the three antigens was of IgG type. The IgG as well as IgM reactivity of LL sera was higher than that of TT and normal sera. The IgG and IgM reactivity of LL and TT sera was maximum with 1C, followed by that with PPD and SS antigens, in that order. This pattern was qualitatively and quantitatively different from that of tuberculosis sera reported previously (Agarwal & Moudgil, 1988).

EPrint Type:Article
Uncontrolled Keywords:Leprosy, IgM, IgG, Serum, Mycobacterium tuberculosis, Lepromatous, Antigens, Antibodies, Enzyme Immunoassay
Subjects:Immunologic and Biological Factors > Immunologic Factors > Antibodies
Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Investigative Techniques > Molecular Probe Techniques
Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Leprosy
Investigative Techniques > Immunologic Techniques
Amino Acids, Peptides, and Proteins > Proteins > Globulins
Immunologic and Biological Factors > Immunologic Factors > Antigens
-Journal Repositories > Indian Journal of Tuberculosis
Diagnosis > Laboratory Techniques and Procedures
ID Code:3267
Deposited By:Mrs Naina Pandita
Deposited On:09 June 2009

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