Glutathione S-Transferase activity and total thiol status in chronic alcohol abusers before and 30 days after alcohol abstinence

Muttigi, M.S.; Prabhu, L.S.; Kedage, V.; Prakash, M.; Shetty, J.K.; Virupaksha, D. and Bhandary, P.V. (2009) Glutathione S-Transferase activity and total thiol status in chronic alcohol abusers before and 30 days after alcohol abstinence. Online Journal of Health and Allied Sciences, 8 (1). ISSN 0972-5997

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Abstract

Background: Glutathione S Transferase (GST) has been involved in detoxification process in the liver and its activity has been shown to be increased in alcohol abusers. In the current work we measured the GST activity, total thiol status, AST, ALT, and direct bilirubin in chronic alcohol abusers before and 30 days after alcohol abstinence and lifestyle modification. Methods: Serum and urine GST activity and total thiol status were determined using spectrophotometric methods and serum transaminases were determined using clinical chemistry analyzer. Results: We found,significant increase in serum and urine GST (p<0.001), AST (p<0.001), ALT (p<0.001), and decrease in total thiol status (p<0.001) in chronic alcohol abusers. GST activity significantly decreased (p<0.001) and total thiol status were improved significantly (p<0.001) 30 days after alcohol abstinence and lifestyle modification. Conclusion: This study provides preliminary data to suggest the role of GST as prognostic indicator of alcohol abstinence with possible trend towards an improvement in liver function.

EPrint Type:Article
Uncontrolled Keywords:Glutathione S Transferase, Total thiols, Alcoholic liver disease, Alcohol abstinence, Bilirubin, Serum Transaminases, Urine, Serum, Thiol
Subjects:Fluids and Secretions > Body Fluids > Urine
Disorders of Environmental Origin > Substance-Related Disorders > Alcohol-Related Disorders
Enzymes and Coenzymes > Enzymes > Transferases
-Journal Repositories > Online Journal of Health and Allied Sciences
Growth Substances, Pigments, and Vitamins > Pigments > Bile Pigments
Organic Chemicals > Sulfur Compounds > Sulfhydryl Compounds
Hemic and Immune Systems > Blood
Digestive System Diseases > Liver Diseases > Liver Diseases, Alcoholic
Digestive System Diseases > Liver Diseases
ID Code:3276
Deposited By:Dr Srinivas Kakkilaya
Deposited On:22 June 2009

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