Total thiols: biomedical importance and their alteration in various disorders

Mungli, Prakash; Shetty, Mahesh S; Tilak, Prasiddha and Anwar, Naureen (2009) Total thiols: biomedical importance and their alteration in various disorders. Online Journal of Health andAllied Sciences, 8 (2). ISSN 0972-5997

Full text available as:

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
237 Kb

Abstract

Thiols are the organic compounds that contain a sulphydryl group. Among all the antioxidants that are available in the body, thiols constitute the major portion of the total body antioxidants and they play a significant role in defense against reactive oxygen species. Total thiols composed of both intracellular and extracellular thiols either in the free form as oxidized or reduced glutathione, or thiols bound to proteins. Among the thiols that are bound to proteins, albumin makes the major portion of the protein bound thiols, which binds to sufhydryl group at its cysteine-34 portion. Apart from their role in defense against free radicals, thiols share significant role in detoxification, signal transduction, apoptosis and various other functions at molecular level. The thiol status in the body can be assessed easily by determining the serum levels of thiols. Decreased levels of thiols has been noted in various medical disorders including chronic renal failure and other disorders related to kidney, cardiovascular disorders, stroke and other neurological disorders, diabetes mellitus, alcoholic cirrhosis and various other disorders. Therapy using thiols has been under investigation for certain disorders

EPrint Type:Article
Uncontrolled Keywords:Thiols, Antioxidants, Glutathione, Free Radicals, Kidney Diseases, Cysteine-SH, Y-glutamyl Cycle
Subjects:-Journal Repositories > Online Journal of Health and Allied Sciences
Organic Chemicals > Sulfur Compounds > Sulfhydryl Compounds
Biochemical Phenomena, Metabolism, and Nutrition > Biochemical Phenomena
Inorganic Chemicals > Free Radicals
Chemical Actions and Uses > Pharmacologic Actions
Organic Chemicals > Free Radicals
Chemical Actions and Uses > Specialty Uses of Chemicals > Protective Agents
Urologic and Male Genital Diseases > Urologic Diseases > Kidney Diseases
ID Code:3370
Deposited By:Dr Srinivas Kakkilaya
Deposited On:29 September 2009

Archive Staff Only: edit this record