Adenosine deaminase activity in cerebrospinal fluid for diagnosis of tuberculous meningitis

Prasad, Rajendra; Kumar, Anil; Khanna, B.K.; Mukerji, P.K.; Agarwal, S.K.; Kumar, A. and Srivastava, V.M.L. (1991) Adenosine deaminase activity in cerebrospinal fluid for diagnosis of tuberculous meningitis. Indian Journal of Tuberculosis, 38 (2). pp. 99-102.

Full text available as:

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
220 Kb

Abstract

Adenosine deaminase activity (ADA) was studied in cerebrospinal fluid of 29 cases of tuberculous meningitis, 15 cases of pyogenic meningitis, 12 cases of aseptic meningitis and 20 controls (patients without any neurological disorders who were given spinal anaesthesia)The mean cerebrospinal fluid adenosine deaminase activity was respectively 6.43 ± 1.93; 1.89 ± 0.91; 0.90 + 0.45 and 0.64 ± 0.57 IU/L in tuberculous meningitis, pyogenic meningitis, aseptic meningitis and controls. The adenosine deaminase activity in tuberculous meningitis cases was significantly higher, The sensitivity and specificity of this test for diagnosis of tuberculous meningitis was 100% and 97.87% respectively with ADA value of more than 3.30 IU/L. Thus, adenosine deaminase activity in CSF, a relatively inexpensive and easy procedure, can be of great value in the diagnosis of tuberculous meningitis

EPrint Type:Article
Uncontrolled Keywords:Adenosine Deaminase Activity, Cerebrospinal Fluid, Tuberculous Meningitis, Pyogenic Meningitis, Aseptic Meningitis, Mycobacterium tuberculosis, Mantoux test, Chest X-Ray, Skull X-Ray
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
Enzymes and Coenzymes > Enzymes > Hydrolases
Bacterial Infections and Mycoses > Bacterial Infections > Central Nervous System Bacterial Infections
Nervous System Diseases > Central Nervous System Diseases > Meningitis
Bacterial Infections and Mycoses > Central Nervous System Infections > Central Nervous System Bacterial Infections
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Fluids and Secretions > Body Fluids
Virus Diseases > Meningitis, Viral > Meningitis, Aseptic
Diagnosis > Diagnostic Techniques and Procedures > Diagnostic Imaging > Radiography
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:3387
Deposited By:Mrs Naina Pandita
Deposited On:07 October 2009

Archive Staff Only: edit this record