Adenosine deaminase activity in cerebrospinal fluid for diagnosis of tuberculous meningitis
Prasad, Rajendra; Kumar, Anil; Khanna, B.K.; Mukerji, P.K.; Agarwal, S.K.; Kumar, A. and Srivastava, V.M.L. (1991) Adenosine deaminase activity in cerebrospinal fluid for diagnosis of tuberculous meningitis. Indian Journal of Tuberculosis, 38 (2). pp. 99-102.
Full text available as:
Adenosine deaminase activity (ADA) was studied in cerebrospinal fluid of 29 cases of tuberculous meningitis, 15 cases of pyogenic meningitis, 12 cases of aseptic meningitis and 20 controls (patients without any neurological disorders who were given spinal anaesthesia)The mean cerebrospinal fluid adenosine deaminase activity was respectively 6.43 ± 1.93; 1.89 ± 0.91; 0.90 + 0.45 and 0.64 ± 0.57 IU/L in tuberculous meningitis, pyogenic meningitis, aseptic meningitis and controls. The adenosine deaminase activity in tuberculous meningitis cases was significantly higher, The sensitivity and specificity of this test for diagnosis of tuberculous meningitis was 100% and 97.87% respectively with ADA value of more than 3.30 IU/L. Thus, adenosine deaminase activity in CSF, a relatively inexpensive and easy procedure, can be of great value in the diagnosis of tuberculous meningitis
Archive Staff Only: edit this record