Tuberculin skin sensitivity following chemoprophylaxis in an island community
Chakraborty, A.K.; Channabasavaiah, R.; Krishnamurthy, M.S.; Shashidhara, A.N. and Motiram, G. (1991) Tuberculin skin sensitivity following chemoprophylaxis in an island community. Indian Journal of Tuberculosis, 38 (4). pp. 201-211.
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As part of an intensified tuberculosis control programme, 4,050 of the 4,118 children aged 5 to 14 years registered in all the 15 villages of Car Nicobar Island were tuberculin tested with ITU RT 23 with Tween 80. they were then administered INH chemoprophylaxis for six months with 98.6% compliance. After 16 months1,209 of these children in seven out of the 15village were retested with the same tuberculin. Mean size of tuberculin indurations had decreased substantially at resting and about 73% to77% of the initially tuberculin positive children had changed over to tuberculin negative status.Besides, there was almost no change in the tuberculin test status of those who were initially categorized as tuberculin negative. The distribution of differences in tuberculin indurations in children before and after mass chemoprophylaxis was found to be unimodal, as compared to the expected bimodal curve in the population having no such intervention. The findings have been attributed to the effect of planned intervention which included chemoprophylaxis
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