A randomized, double blind, placebo controlled study evaluating preventive role of gabapentin for PONV in patients undergoing laparascopic cholecystectomy

Bashir, F.; Mohd, K.; Qazi, S. and Hashia, A.M (2009) A randomized, double blind, placebo controlled study evaluating preventive role of gabapentin for PONV in patients undergoing laparascopic cholecystectomy. JK Science, 11 (4). pp. 190-193. ISSN 0972-1177

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Abstract

A double blind, prospective, randomized placebo controlled study was carried out to evaluate the antiemetic efficacy of Gabapentin on incidence and severity of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy under general anaesthesia. One hundred patients of ASA grade I & II randomly assigned equally in two groups were given 600mg of gabapentin or matching placebo orally two hours before surgery. A complete response (no nausea and vomiting) was observed in 60% patients in gabapentin group as compared to 38.2% in Placebo group. The difference was statiscally significant (P = 0.028). In addition use of rescue antiemetics was reduced in gabapentin group to 34% (17 patients) compared to placebo group 54% (27 patients) with a statistically significant difference ( P = 0.044). However, there was no difference of severity of PONV amongst two groups; 1st, 2nd, 6th, 12th and 24th. hour of surgery. The study reveals that gabapentin, an anticonvulsant and analgesic may prove to be multimodal when further research is conducted to prove its efficacy as antiemetic.

EPrint Type:Article
Additional Information:Originals Articles
Uncontrolled Keywords:Gabapentin, Postoperative Nausea, Vomiting, Anaesthesia, Laparoscopic,Cholecystectomy, Patients, Postoperative Complications
Subjects:Pathological Conditions, Signs and Symptoms > Pathologic Processes > Postoperative Complications
Organic Chemicals > Amines
Surgical Procedures, Operative > Surgical Procedures, Minimally Invasive > Endoscopy > Laparoscopy
Surgical Procedures, Operative > Postoperative Care
Surgical Procedures, Operative > Postoperative Period
Surgical Procedures, Operative > Digestive System Surgical Procedures
Therapeutics > Patient Care
Therapeutics > Placebos
Anesthesia and Analgesia > Anesthesia Recovery Period
Pathological Conditions, Signs and Symptoms > Signs and Symptoms > Signs and Symptoms, Digestive
Organic Chemicals > Carboxylic Acids > Acids, Acyclic
Persons > Patients
Digestive System Diseases > Biliary Tract Diseases > Gallbladder Diseases
-Journal Repositories > JK Science
Pharmaceutical Preparations > Placebos
Anesthesia and Analgesia > Anesthesia
ID Code:3414
Deposited By:JK Science: Journal of Medical Education and Research
Deposited On:29 October 2009

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