Association of HLA B1502 allele and carbamazepine-induced Stevens–Johnson syndrome among Indians

Mehta, Timir Y.; Prajapati, Laxman M.; Mittal, Bharti; Joshi, C.G.; Sheth, Jayesh J.; Patel, Dinesh B.; Dave, Dinkar M. and Goyal, Ramesh K. (2009) Association of HLA B1502 allele and carbamazepine-induced Stevens–Johnson syndrome among Indians. Indian Journal of Demarmatology, Venereology & Laprology, 75 (6). pp. 579-582. ISSN 0378-6323

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Background: Stevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulÞ lled the diagnostic criteria of SJS induced by carbamazepine were identiÞ ed and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-speciÞ c primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepineinduced SJS in Indian patients.

EPrint Type:Article
Uncontrolled Keywords:Carbamazepine, HLA-B*1502, Hindu, Indian, Stevens–Johnson syndrome
Subjects:-Institutional Repositories > College of Veterinary Science and Animal Husbandry (Anand Agricultural University)
Stomatognathic Diseases > Mouth Diseases > Stomatitis
Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Abnormalities > Abnormalities, Drug-Induced
Pathological Conditions, Signs and Symptoms > Pathologic Processes > Necrosis
Chemical and Pharmacologic Phenomena > Drug Interactions
Skin and Connective Tissue Diseases > Skin Diseases > Skin Diseases, Vesiculobullous
Skin and Connective Tissue Diseases > Skin Diseases > Erythema
Immunologic and Biological Factors > Immunologic Factors > Antigens > Isoantigens > Antigens, Human Platelet
Biological Sciences > Biotechnology
ID Code:3461
Deposited By:Dr Prakash Koringa
Deposited On:23 November 2009

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