Renal and hepatic dysfunction in malaria patients in Minna, North Central Nigeria

Ogbadoyi, Emmanuel O. and Tsado, Ruth D. (2009) Renal and hepatic dysfunction in malaria patients in Minna, North Central Nigeria. Online Journal of Health andAllied Sciences, 8 (3). ISSN 0972-5997

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Abstract

Information on kidney and liver involvement in malaria in Africa is still very scanty. Kidney and liver functions were assessed in 70 malaria patients using serum levels of creatinine and urea and urinary protein levels as test indicators of kidney function and serum levels of bilirubin, aspartate aminotranferase (AST or SGOT), alanine aminotransferase (ALT or SGPT), and alkaline phosphatase (ALP) as indicators of liver function. Descriptive analysis of results obtained showed that 67.14% of patients had creatinine level above the 126µmole/L which is considered the upper limit of the normal range. Three cases (4.29%) had creatinine levels well above 265µmoles/L. The serum concentrations of creatinine, urea, protein, conjugated and total bilirubin, AST, ALT, and ALP in malaria patients were significantly higher (p<0.05) than those of malaria free individuals. We conclude that renal dysfunction, acute renal failure and liver dysfunction are clinical features of malaria in Minna, North Central Nigeria.

EPrint Type:Article
Uncontrolled Keywords:Malaria, Transferases, Creatinine, Bilirubin, Hepatic Dysfunction, Renal Dysfunction, Asparate Aminotransferase, Bilirubin, Creatinine, North Central Nigeria, Alanine Aminotransferase, Alkaline phosphatase
Subjects:Digestive System Diseases > Liver Diseases > Liver Diseases, Parasitic
Enzymes and Coenzymes > Enzymes > Hydrolases
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Tetrapyrroles
Enzymes and Coenzymes > Enzymes > Transferases
Urologic and Male Genital Diseases > Urologic Diseases > Kidney Diseases
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Imidazoles
-Journal Repositories > Online Journal of Health and Allied Sciences
Growth Substances, Pigments, and Vitamins > Pigments > Bile Pigments
Parasitic Diseases > Protozoan Infections > Coccidiosis > Malaria
Geographic Locations > Africa > Africa South of the Sahara > Africa, Western > Nigeria
Digestive System Diseases > Liver Diseases
ID Code:3520
Deposited By:Dr Srinivas Kakkilaya
Deposited On:09 September 2010

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