Study of early predictors of fatality in mechanically ventilated neonates in NICU

Trivedi, Sangeeta S.; Chudasama, Rajesh K. and Srivastava, Anurakti (2009) Study of early predictors of fatality in mechanically ventilated neonates in NICU. Online Journal of Health andAllied Sciences, 8 (3). ISSN 0972-5997

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Objective: To evaluate the risk factors associated with fatality in mechanically ventilated neonates using multiple regression analysis. Design & settings: Prospective study conducted at Neonatal ICU at New Civil Hospital, Surat – a tertiary care centre, from December, 2007 to May, 2008 for 6 months. Methods: Fifty neonates in NICU consecutively put on mechanical ventilator during study period were enrolled in the study. The pressure limited time cycled ventilator was used. All admitted neonates were subjected to an arterial blood gas analysis along with a set of investigations to look for pulmonary maturity, infections, renal function, hyperbilirubinemia, intraventricular hemorrhage and congenital anomalies. Different investigation facilities were used as and when required during ventilation of neonates. Multiple logistic regression analysis was done to find out the predictors of fatality among these neonates. Results: Various factors suspected as predictors of fatality of mechanically ventilated neonates were assessed. Hypothermia, prolonged capillary refill time (CRT), initial requirement of oxygen fraction (FiO2) >0.6, alveolar to arterial PO2 difference (AaDO2) >250, alveolar to arterial PO2 ratio (a/A) <0.25, & oxygenation index (OI) >10 were found statistically highly significant predictors of mortality among mechanically ventilated neonates. Conclusion: Hypothermia and prolonged capillary refill time were independent predictors of fatality in neonatal mechanical ventilation. Risk of fatality can be identified in mechanically ventilated neonates

EPrint Type:Article
Uncontrolled Keywords:Mechanical Ventilation, Neonates, Hypothermia, Capillary Refill Time
Subjects:Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Infant, Newborn, Diseases
-Journal Repositories > Online Journal of Health and Allied Sciences
Persons > Age Groups > Infant > Infant, Newborn
Respiratory Tract Diseases > Lung Diseases > Respiratory Distress Syndrome, Newborn
Equipment and Supplies > Ventilators, Mechanical
ID Code:3521
Deposited By:Dr Srinivas Kakkilaya
Deposited On:08 September 2010

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