A prospective analysis of adverse drug reactions in a South Indian hospital

Uday Kumar, Padmaja; Adhikari, Prabha and Periera, Pratibha (2009) A prospective analysis of adverse drug reactions in a South Indian hospital. Online Journal of Health and Allied Sciences, 8 (3). ISSN 0972-5997

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Adverse drug reactions are a great cause of concern to the medical profession, the patients and the pharmaceutical industry. However ADR reporting and monitoring is yet to catch up in India. Hence we undertook a study to record and analyze adverse reactions among all patients admitted to the medical wards of a tertiary care. Centre patients admitted to all medical wards over one year were assessed for ADRs throughout their admission. Suspected ADRs were recorded and analyzed for i) the type of reaction ii) severity iii) Consequence on treatment that is if the drug was continued, or stopped, or needed to be treated with other drugs, iv) Physiological system involved and the v) group of the drugs associated with ADRs. Among 1250 patients admitted during the study period, 250 adverse events were observed. Majority (76.8%) were of mild type, 66% were severe requiring intensive care and 3 patients died. Antimicrobials were responsible for maximum (42.4%) ADRs followed by drugs acting on CNS (20%). When we analyzed the systems affected, CNS side effects were more common in our study. While in many other studies Cardiovascular and gastrointestinal side effects were the most common. Combination of drugs was responsible for a large percentage of ADRs. Inadvertent use of antipsychotics with sedatives led to respiratory failure in 4 patients of which 1 died. Contaminated IV fluids are suspected to be the cause of death in another fatal ADR. In conclusion there is a need for vigilant ADR monitoring to be done by all doctors to prevent morbidity and mortality from ADRs

EPrint Type:Article
Uncontrolled Keywords:Adverse Drug Reactions, Monitoring, Antimicrobials, Drugs, Drug Combination, Hospital, South India
Subjects:Disorders of Environmental Origin > Poisoning > Drug Toxicity
Health Care Facilities, Manpower, and Services > Health Services
Therapeutics > Drug Therapy
Chemical Actions and Uses > Pharmacologic Actions > Physiological Effects of Drugs
Pharmaceutical Preparations > Drug Combinations
Immunologic Diseases > Hypersensitivity > Drug Hypersensitivity
Therapeutics > Patient Care
-Journal Repositories > Online Journal of Health and Allied Sciences
Chemical and Pharmacologic Phenomena > Drug Interactions
Persons > Patients
Information Science > Information Services
Health Services Administration > Patient Care Management
ID Code:3524
Deposited By:Dr Srinivas Kakkilaya
Deposited On:08 September 2010

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