The effects of sildenafil citrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus): a histological study

Eweka, A.O. and Eweka A, A. (2010) The effects of sildenafil citrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus): a histological study. Online Journal of Health andAllied Sciences, 9 (1). ISSN 0972-5997

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Abstract

The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely the lateral geniculate body (LGB) of adult Wistar rat was carefully studied. The rats of both sexes (n=24), average weight of 202g were randomly assigned into three treatment (n=18) and control (n=6) groups. The rats in the treatment groups ‘A’, ‘B’ and ‘C’ received respectively, 0.25mg/kg, 0.70mg/kg and 1.43mg/kg body weight of sildenafil citrate base dissolved in distilled water daily for 30 days, through orogastric feeding tube, while that of the control group D, received equal volume of distilled water daily during the period of the experiment. The rats were fed with growers’ mash obtained from Edo Feeds and Flour Mill Ltd, Ewu, Edo State, Nigeria and were given water liberally. The rats were sacrificed on day thirty-one of the experiment. The lateral geniculate body (LGB) was carefully dissected out and quickly fixed in 10% formal saline for histological studies. The histological findings after H&E method indicated that the treated section of the lateral geniculate body (LGB) showed some varying degree of reduced cellular population based on its sparse distribution, degenerative changes, cellular hypertrophy, and intercellular vacuolations appearing in the stroma. Varying dosage and long administration of sildenafil citrate may have some deleterious effects on the neurons of the intracranial visual relay centre and this may probably have some adverse effects on visual sensibilities by its deleterious effects on the cells of the lateral geniculate body (LGB) of adult Wistar rats. It is therefore recommended that further studies aimed at corroborating these observations be carried out.

EPrint Type:Article
Uncontrolled Keywords:Sildenafil Citrate, Lateral Geniculate Body, Decreased Cellular Population, Cellular Hypertrophy, Vacuolations, Wistar Rats, Viagra
Subjects:Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Purines
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Piperazines
Nervous System > Central Nervous System
Animals > Chordata > Vertebrates > Mammals > Rodentia > Muridae > Rats
Chemical Actions and Uses > Pharmacologic Actions > Therapeutic Uses > Central Nervous System Agents
-Journal Repositories > Online Journal of Health and Allied Sciences
Pathological Conditions, Signs and Symptoms > Pathological Conditions, Anatomical > Hypertrophy
Organic Chemicals > Sulfur Compounds > Sulfones
ID Code:3554
Deposited By:Dr Srinivas Kakkilaya
Deposited On:21 September 2010

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