Quantitative assay of arsenic in experimentally intoxicated guinea Pigs

Kumar, Dinesh; Srivastava, A.K. and Kumar, Sanjiv (2010) Quantitative assay of arsenic in experimentally intoxicated guinea Pigs. Veterinary World, 3 (10). pp. 463-465. ISSN 0972-8988

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The present investigation was undertaken with an attempt to generate information pertaining to the assessment of arsenic residues in the vital organs like liver, lungs kidneys along with blood and hair as biomarker of chronic arsenic exposure using guinea pigs as experimental animal. For this purpose the guinea pigs were divided into two groups having 5 animals in each group. Group I animals were fed 1% of Arsenic trioxide @ 1 mg/kg body weight through oral gavages daily for 90 days to produce chronic toxicity. Estimation of arsenic residue was carried out on 90th day post administration. In the present study chronic exposure to arsenic resulted in significant enhancement of arsenic residues in the blood, hair, liver, lungs and kidneys with mean values of 57.18, 333.71, 331.96, 95.8 ppb and 272.95 in guinea pigs of chronic toxicity as compared to 3.47, 14.02, 12.94, 2.56 and 5.56 ppb in control, respectively.

EPrint Type:Article
Uncontrolled Keywords:Arsenic, Biomarker, Wet digestion, Tissue Arsenic concentration, Guinea Pigs
Subjects:Investigative Techniques > Models, Animal
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
-Journal Repositories > Veterinary World
Inorganic Chemicals > Elements > Arsenic
Investigative Techniques > Animal Experimentation
Diagnosis > Laboratory Techniques and Procedures
Disorders of Environmental Origin > Poisoning > Arsenic Poisoning
ID Code:3602
Deposited By:Dr Anjum Sherasiya
Deposited On:09 November 2010

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