Urinary peptide levels in patients with chronic renal failure

Mungli, Prakash; Phani, Nagaraj M.; Kavya, R. and Supriya, M. (2010) Urinary peptide levels in patients with chronic renal failure. Online Journal of Health and Allied Sciences, 9 (3). ISSN 0972-5997

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Introduction: Peptide levels in urine are found to be decreased in renal failure. In the current study urinary peptide levels were determined in chronic renal failure (CRF) patients. Method: 86 CRF patients and 80 healthy controls were selected for the study. Urinary proteins and peptide levels were determined by spectrophotometer based Lowry and Bradford methods. Urinary creatinine levels were determined by clinical chemistry analyzer. Results: There was significant decrease in urinary peptide levels in CRF patients and Urinary % peptides were significantly decreased in CRF patients as compared to healthy controls. Urinary % peptides correlated negatively with proteinuria. Conclusion: we have found decrease in urinary peptides and % urinary peptides in CRF patients and possibly measurement of % urinary peptides may possibly serve as better indicator in early detection of impairment in renal function.

EPrint Type:Article
Uncontrolled Keywords:Peptiduria; Proteinuria; Chronic renal failure; Urinary peptides
Subjects:Amino Acids, Peptides, and Proteins > Peptides
-Journal Repositories > Online Journal of Health and Allied Sciences
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Azoles
Persons > Patients
Fluids and Secretions > Body Fluids > Urine
Urologic and Male Genital Diseases > Urologic Diseases > Kidney Diseases
ID Code:3609
Deposited By:Dr Srinivas Kakkilaya
Deposited On:02 December 2010

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