Total thiols and MDA levels in patients with acute myocardial infarction before and after reperfusion therapy

Babu, Suresh; Shetty, Jeevan K. and Mungli, Prakash (2010) Total thiols and MDA levels in patients with acute myocardial infarction before and after reperfusion therapy. Online Journal of Health and Allied Sciences, 9 (3). ISSN 0972-5997

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Abstract

Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.

EPrint Type:Article
Uncontrolled Keywords:MDA; Total Thiols; Myocardial infarction; Reperfusion injury
Subjects:Surgical Procedures, Operative > Cardiovascular Surgical Procedures
Cardiovascular Diseases > Heart Diseases > Myocardial Ischemia
-Journal Repositories > Online Journal of Health and Allied Sciences
Organic Chemicals > Sulfur Compounds > Sulfhydryl Compounds
Investigative Techniques > Perfusion
Organic Chemicals > Aldehydes > Malondialdehyde
ID Code:3610
Deposited By:Dr Srinivas Kakkilaya
Deposited On:25 November 2010

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