Examination of multiple sputum specimens in tuberculosis survey.
Chandrashekar, P.; Nair, S.S.; Rao, K.Padmanabha; Rao, G.Ramanath and Pyarelal, Dr. (1970) Examination of multiple sputum specimens in tuberculosis survey. Tubercle, 51 (3). pp. 255-262.
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During an epidemiological survey, four specimens of sputum were collected within seven days from each person with an abnormal chest x-ray in 30 villages in a district of South India. Each specimen was examined by fluorescence microscopy, Ziehl-Neelsen technique and culture. There were 34 culture-positives among the 2,164 persons for whom all the four culture examinations were available. Out of these, on average, 21(62 %) were found from examination of one specimen only. An estimate of prevalence obtained from only one sputum specimen will have to be multiplied by 1.67 to get the prevalence that would be obtained from many specimens. Similarly, the correction factor for estimates based on two sputum specimens will be 1.26.
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