Tuberculin sensitivity among children vaccinated with BCG under universal immunization programme

Chadha, V.K.; Jaganath, P.S. and Kumar, P. (2004) Tuberculin sensitivity among children vaccinated with BCG under universal immunization programme. Indian Journal of Pediatrics, 71 (12). pp. 1063-1068.

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A tuberculin survey was conducted among 45988 children with BCG scar and 54227 children without BCG scar between 1-9 years of age and residing in selected rural areas of three defined zones of India. About 45-60% of the BCGvaccinated children elicited reactions <5 mm in size and about 70-80% had reactions <10 mm. Therefore, in the majority of children (showing tuberculin reaction of <10 mm), BCG-induced tuberculin sensitivity does not interfere with interpretation of tuberculin test. The study also revealed that a proportion of reactions among BCG vaccinated children in 5-9 mm, 10-14 mm and 15-19 mm range may be attributable to BCG vaccination. Therefore, reactions between 10-14 mm and especially 15-19 mm among the vaccinated children must be interpreted carefully. However, 19 mm was observed as the upper limit for BCG induced tuberculin sensitivity and all reactions ³ 20 mm in size may be considered to be due to infection with tubercle bacilli, irrespective of the BCG vaccination status.

EPrint Type:Article
Uncontrolled Keywords:Tuberculosis; Infection; Tuberculin test; BCG vaccination
Subjects:Persons > Age Groups > Child
Therapeutics > Biological Therapy > Immunotherapy > Immunization
Diagnosis > Diagnostic Techniques and Procedures > Skin Tests > Tuberculin Test
-Institutional Repositories > National Tuberculosis Institute
Immunologic and Biological Factors > Biological Products > Vaccines > Bacterial Vaccines > Tuberculosis Vaccines > BCG Vaccine
ID Code:395
Deposited By:Librarian Sudha S Murthy
Deposited On:28 July 2005

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