Freeze dried BCG vaccine sealed in presence of nitrogen
Bhushan, Kul; Baily, G.V.J.; Nair, S.S.; Ganapathy, K.T. and Singh, Vijay (1975) Freeze dried BCG vaccine sealed in presence of nitrogen. Indian Journal of Medical Research, 63 (9). pp. 1335-1343.
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Because of the obvious operational economical, and technical advantages of the freeze dried BCG vaccine sealed in presence of nitrogen, it was compared with the standard freeze-dried BCG vaccine sealed in vacuum, when stored at different temperatures (4oC. 37oC., and 44oC.) for 2, 6 and 18 weeks each. It was found that in terms of post-vaccination allergy and size of vaccination lesion, the vaccines sealed by either method were not affected when stored at 4oC up to l8 weeks or at 37°C for two weeks. For other periods both types of vaccines were affected badly when stored at 37°C and for any period at 44°C. Viable counts for the vaccine sealed in presence of nitrogen, however, reduced rapidly with time.
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