Tumor necrosis factor alpha receptors p55 and p75 and ovarian cancer: state-of-the-art research and clinical implications

Rzymski, Pawel P (2005) Tumor necrosis factor alpha receptors p55 and p75 and ovarian cancer: state-of-the-art research and clinical implications. Archives of Medical Science, 1 (1). pp. 3-7. ISSN 1734-1922

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Abstract

Tumor Necrosis Factor a acts via its two cell-surface receptors p55 and p75 and the effect depends on their activation. Receptors are proteins that dissociate from cell surface and become soluble molecules in serum blocking the natural activity of TNFα. It has been proved that this cytokine and both receptors could be overexpressed and constitutively produced by many malignant tumors, including ovarian cancer. However, little is known about the ovarian-specific role in cancer biology. Molecular and immunological research was not followed by many clinical evaluations of potential power of TNFα, p55 and p75. Some research supports previous laboratory results. It has been also suggested that especially receptors p55 and p75 could be useful in ovarian cancer detection, differentiation, staging or predicting prognosis, relapse and surgical debulking. Results are inspiring and promising, but should be followed by more well-designed research.

EPrint Type:Article
Additional Information:Archives of Medical Science is published by Termedia Publishing Hause (www.termedia.pl). Archives of Medical Science would like to publish high quality original papers, case reports and short communications made especially by young scientists from all over the world. It is a peer-reviewed journal with international Editorial Board. The second aim of AMS is to present best educational manuscripts (review articles) written by known and famous medical scientists to make this Journal even more interesting for young doctors. The AMS publishes articles on all aspects of basic and clinical research in all fields of medicine, with emphasis on matters of worldwide interest, advances in medicine and research. The Archives of Medical Science is published quarterly.
Uncontrolled Keywords:TNF alpha receptors, CD120a, CD120b, tumor markers, ovarian cancer.
Subjects:Female Genital Diseases and Pregnancy Complications > Genital Diseases, Female > Genital Neoplasms, Female
Immunologic and Biological Factors > Biological Factors > Biological Markers > Tumor Markers, Biological
Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins
-Journal Repositories > Archives of Medical Science
Immunologic and Biological Factors > Immunologic Factors > Cytokines
Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins
Neoplasms > Neoplasms by Site > Endocrine Gland Neoplasms > Ovarian Neoplasms
Immunologic and Biological Factors > Immunologic Factors > Cytokines > Tumor Necrosis Factors > Tumor Necrosis Factor-alpha
Growth Substances, Pigments, and Vitamins > Growth Substances > Intercellular Signaling Peptides and Proteins
ID Code:485
Deposited By:Dr. Maciej / M Banach
Deposited On:01 August 2005

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