Tuberculin test

Chadha, Vineet K. (2001) Tuberculin test. Indian Journal of Pediatrics, 68 (1). pp. 53-58.

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Although tuberculin test is widely used for detection of tuberculous infection among children, there is no clear understanding about its performance and interpretation. This article has been written with the purpose of elucidating the performance and interpretation of standard tuberculin test, based on the experiences gained at the National Tuberculosis Institute, Bangalore and other centres. The standard tuberculin test involves intradermal injection of ‘1TU PPD RT23 with Tween 80’ on the mid-volar aspect of forearm and measurement of the maximum transverse diameter of induration after 3 days. Larger the size of induration, higher is the probability of it being due to tuberculous infection. The majority of reactions with induration size of 15 mm and above are attributable to infection with tubercle bacilli, irrespective of BCG-vaccination status. While indurations of less than 5 mm indicate absence of any kind of tuberculin sensitivity, the majority of indurations in 5-9 mm range are usually of non-tuberculous nature. An induration of 10-14 mm requires more careful interpretation. It is more likely to be attributable to infection with tubercle bacilli in case of history of contact with smear positive case or among children with clinical findings of tuberculosis. However, the size of induration in an infected child may be diminished in the presence of immuno-suppressive conditions. One should also consider the purpose of test while interpreting the test results.

EPrint Type:Article
Uncontrolled Keywords:Tuberculin test; Size of Induration; Infection with tubercle bacilli; Non-specific sensitivity; BCG-induced sensitivity; Purpose of the test.
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
Diagnosis > Diagnostic Techniques and Procedures > Skin Tests
-Institutional Repositories > National Tuberculosis Institute
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Diagnosis > Diagnostic Techniques and Procedures > Skin Tests > Tuberculin Test
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
Immunologic and Biological Factors > Biological Products > Vaccines > Bacterial Vaccines > Tuberculosis Vaccines > BCG Vaccine
ID Code:560
Deposited By:Librarian Sudha S Murthy
Deposited On:03 August 2005

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