Tuberculin testing in a partially vaccinated population

NTI, Bangalore (1992) Tuberculin testing in a partially vaccinated population. Indian Journal of Tuberculosis, 39. pp. 149-158.

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Abstract

To obtain precise information for computing the indices of tuberculosis situation in a community, with passage of time, reliance is placed on tuberculosis infection rates obtained by carrying out tuberculin surveys. In most developing countries, covered extensively by BCG vaccination without prior discrimination by tuberculin testing, the tuberculin test has problems of interpretation for demarcating the infected persons from the uninfected. To overcome the problem, therefore, the test results are analysed among persons who do not show a BCG scar and are, thus, considered as normal population. In this paper, an attempt is made to show that BCG vaccination dose not always lead to the formation of a scar, and also that the scar resulting from BCG vaccination may fade away with time and the person, thus, may be wrongly included in the unvaccinated group. It has also been found that there is greater fading of scars in the younger age groups : in 0-2 years group, upto 52% of the scars faded away within 21 months of vaccination. This proportion steadily decreased to about 8% in the 10-14 years age group. The implication of the finding is that the demarcation line between uninfected and infected persons may require to be shifted from survey to survey, based on the distributions among the ‘no scar’ population. Moreover, in a totally vaccinated community, the differences of reactions may provide the answer to the problem of identifying the newly infected persons.

EPrint Type:Article
Additional Information:This report has been prepared by Dr. A.K. Chakraborty, Additional Director and Dr. K. Chaudhuri, Director, National Tuberculosis Institute, Bangalore-3. The project was originally planned by and field work completed under the guidance of late Dr. Raj Narain, then Epidemiologist, who also prepared the initial draft of the paper.
Uncontrolled Keywords:Tuberculin Testing, Tuberculin, Population, Partial Vaccination
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
Population Characteristics > Population
Persons > Age Groups > Child
-Institutional Repositories > National Tuberculosis Institute
Therapeutics > Biological Therapy > Immunotherapy > Immunization > Immunotherapy, Active > Vaccination
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Diagnosis > Diagnostic Techniques and Procedures > Skin Tests > Tuberculin Test
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
Persons > Age Groups > Adolescent
Immunologic and Biological Factors > Biological Products > Vaccines > Bacterial Vaccines > Tuberculosis Vaccines > BCG Vaccine
ID Code:569
Deposited By:Librarian Sudha S Murthy
Deposited On:04 August 2005

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