Bacterial burden of the patients with coronary artery disease treated surgically with coronary artery bypass grafting

Jegier, Bogdan and Jander, Slawomir (2005) Bacterial burden of the patients with coronary artery disease treated surgically with coronary artery bypass grafting. Archives of Medical Science, 1 (1). pp. 13-17. ISSN 1734-1922

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Background: Infection with Chlamydia pneumoniae, Helicobacter pylori and Mycoplasma pneumoniaeis taken into consideration as a factor influencing development of atherosclerosis. Objective: The aim of the study was an assessment of infectious burden with selected bacterial microorganisms in the patients with advanced atherosclerotic process. Material and methods: The study included 40 patients with three-vessels stable coronary arteries disease referred to the surgical revascularization. Plasma levels of IgG class antibodies anti-Chlamydia pneumoniae, anti-Helicobacter pylori and anti-Mycoplasma pneumoniaewere determined with the tests based on the ELISA technique (Enzyme linked Immunosorbent Assay). Results: In the study group, plasma IgG class antibodies anti-Helicobacter pylori (n=35, f=0.875, p<0.05) and a combination of antibodies anti-Helicobacter pylori and anti-Chlamydia pneumoniae (n=17, f=0.81, p<0.001) were significantly more frequently detected in comparison with the other antibodies. Conclusions: The results of the study may suggest a participation of bacterial factor in the atherosclerotic process developing in coronary arteries. In stable advanced three-vessels coronary arteries disease the infection with two kinds of pathogens was significantly more frequently detected. However, our findings did not allow to determine a role of bacterial infection in etiopathogenesis of atherosclerosis

EPrint Type:Article
Additional Information:Archives of Medical Science would like to publish high quality original papers, case reports and short communications made especially by young scientists from all over the world. It is a peer-reviewed journal with international Editorial Board. The second aim of AMS is to present best educational manuscripts (review articles) written by known and famous medical scientists to make this Journal even more interesting for young doctors. The AMS publishes articles on all aspects of basic and clinical research in all fields of medicine, with emphasis on matters of worldwide interest, advances in medicine and research. The Archives of Medical Science will be published quarterly.
Uncontrolled Keywords:Chlamydia pneumoniae, Helicobacter pylori, Mycoplasma pneumoniae, atherosclerosis, coronary artery by-pass grafting.
Subjects:Bacteria > Gram-Positive Bacteria
Cardiovascular Diseases > Vascular Diseases > Arteritis
Cardiovascular Diseases > Vascular Diseases > Arterial Occlusive Diseases
-Journal Repositories > Archives of Medical Science
Bacteria > Gram-Negative Bacteria
Cardiovascular Diseases > Vascular Diseases > Embolism and Thrombosis
ID Code:589
Deposited By:Dr. Maciej / M Banach
Deposited On:05 August 2005

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