The effect of hormone replacement therapy on the left ventricle systolic and diastolic function in postmenopausal women with coronary artery disease

Bręborowicz, Piotr; Mularek-Kubzdela, Tatiana; Oko-Sarnowska,, Zofia; Trojnarska, Olga; Maciejewska, Marzena; Bręborowicz, Elżbieta; Warenik-Szymankiewicz, Alina and Cieśliński, Andrzej (2005) The effect of hormone replacement therapy on the left ventricle systolic and diastolic function in postmenopausal women with coronary artery disease. Archives of Medical Science, 1 (1). pp. 18-22. ISSN 1734-1922

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Abstract

Introduction: The aim of this study was to evaluate the effect of hormone replacement therapy (HRT) on the left ventricle systolic and diastolic function. Materials and methods: Fifty-six postmenopausal women with proven coronary artery disease (CAD) were enrolled into the study (31 were assigned to HRT and 25 were matched as a control group). Clinically both groups were comparable. All patients had standard 2D and Doppler echocardiography study at the baseline and after 12 months of follow up. Results: The heart geometry and wall thickness did not change significantly in both groups and were comparable after 12-months of follow-up: EDD: 45.6±6.0 to 44.6±8.1 vs. 47.8±7.1 to 47.2±4.4; ESD: 29.5±7.1 to 29±8.8 vs. 34.3±6.7 to 34.4±7.7; RV: 21.9±6.1 to 23.1±7 vs. 21.5±5.8 to 21.8±3.2; LA: 32±4.7 to 35.6±7.9 vs. 34.3±4.2 to 34±4.4; Ao: 28.8±3.3 to 29.2±4.5 vs. 28.8±2.2 to 28.5±3.4; IVS: 9.9±1.4 to 10±1 vs. 10±1.3 to 10.3±1.6; PW: 10.2±1.1 to 10±1 vs. 10.1±1.6 to 10.3±1.4. Left ventricle systolic and diastolic parameters did not change significantly in both groups and were comparable after 12-months of follow-up: LVEF (%): 64.3±13.4 to 68.4±14.9 vs. 56.6±12.5 to 59.9±13; ESV (ml): 35.3±39.8 to 40.4±57.2 vs. 42.9±23.9 to 38.6±16.4; IVRT (ms): 120.9±22.8 to 112.2±15.4 to 112.8±27.7 to 109.3±12.8; E: A: 1.17±1.17 to 1±0.48 vs. 0.97±0.41 to 0.94±0.35; DCT (E) (ms): 152.4±70.6 to 150.2±50.9 vs. 149.3±69.1 to 176.8±61.4; EDV (ml): 84.9±62.6 to 98.3±69.7 vs. 96.9±43.6 to 96.1±26.9. Conclusions: Short term transdermal HRT has no effect on the left ventricle systolic and diastolic function in women with CAD.

EPrint Type:Article
Additional Information:Archives of Medical Science would like to publish high quality original papers, case reports and short communications made especially by young scientists from all over the world. It is a peer-reviewed journal with international Editorial Board. The second aim of AMS is to present best educational manuscripts (review articles) written by known and famous medical scientists to make this Journal even more interesting for young doctors. The AMS publishes articles on all aspects of basic and clinical research in all fields of medicine, with emphasis on matters of worldwide interest, advances in medicine and research. The Archives of Medical Science will be published quarterly.
Uncontrolled Keywords:hormone replacement therapy, HRT, estrogens, menopause, coronary artery disease, CAD, echocardiography, systolic function, diastolic function.
Subjects:Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Gonadotropins
Cardiovascular Diseases > Heart Diseases > Myocardial Ischemia
Persons > Women
-Journal Repositories > Archives of Medical Science
Reproductive and Urinary Physiology > Reproduction
Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Gonadal Hormones
Therapeutics > Drug Therapy > Hormone Replacement Therapy
ID Code:601
Deposited By:Dr. Maciej / M Banach
Deposited On:06 August 2005

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