Estimation of annual risk of tuberculosis infection among BCG vaccinated children
Chadha, V.K.; Krishna Murthy, M.S.; Shashidhara, A.N.; Jagannath, P.S. and Magesh, V. (1999) Estimation of annual risk of tuberculosis infection among BCG vaccinated children. Indian Journal of Tuberculosis, 46. pp. 105-112.
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Two tuberculin surveys with an average interval of three years had been carried out in the peri-urban areas of Bangalore city where B.C.G. vaccination coverage among children was good. Feasibility of estimating the annual risk of tuberculosis infection in that area, even among the BCG vaccinated children, was explored using two different techniques. In the first technique, distributions of tuberculosis reaction were compared. Since the distributions of tuberculin reactions among the BCG vaccinated and the unvaccinated children were similar in both the surveys, it was found feasible to estimate the ARI including the BCG vaccinated children. In another technique, using the distribution of differences in tuberculin reactions, children with BCG scar showing an increase of > 15 mm between the two tuberculin tests were found to cluster into a distinct group. These probably represent the children newly infected with M. tuberculosis during the period interventing between surveys. It was concluded that in similar areas the annual risk of infection could be estimated using the BCG vaccinated children.
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