The fate of resistant cases treated with three different drug regimens of short course chemotherapy under programme conditions

Jagota, P.; Srinivas, T.R.; Parimala, N. and Chaudhuri, K. (1990) The fate of resistant cases treated with three different drug regimens of short course chemotherapy under programme conditions. Indian Journal of Tuberculosis, 37. pp. 83-87.

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Abstract

The fate of patients with Isoniazid (H) resistant pulmonary tuberculosis, treated with 3 different Short Course Chemotherapy regimens (Regimen A - 1 SHRZ/7 TH, Regimen B - 2 SHR/6 TH, Regimen C-2 EHR/4H2R2 was examined in two sequential studies. One hundred H resistant patients belonging to two groups-one without history of previous treatment (core group) and second with history of previous treatment ≥ 15 days (non-core group) were followed up at the end of 12th, 15th and 24th/36th month of chemotherapy. The satisfactory bacteriological response among patients in the core group at the end of chemotherapy with Regimen A, B and C was 65.2% of 23 patients, 50% of 18 patients, and 57.1% of 18 patients respectively. The response among patients in the non-core group was 27.3% with Regimen A and 52.6% with Regimen B. At the end of 24th/36th month of chemotherapy 62.5% patients on Regimen A and 68.7% patients on Regimen C in the core group and 41.7% patients on Regimen B in the non-core group (not calculated for non-core group of Regimen A and core group of Regimen B due to low coverage) became culture negative. There is a significant different between the relapse rates for Regimen A, Regimen B and Regimen C (P > 0.05). There were 9 deaths at the end of the last follow up and most of them were those who were culture positive at the end of the chemotherapy.

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