Role of nontuberculuos infection in immunization against tuberculosis
Challu, Vijay K.; Chandrasekaran, Sujatha; Sreenivas, T.R.; Chauhan, M.M.; Jones, B.; Rajalakshmi, R.; Mahadev, B.; Balasangameshwara, V.H. and Chaudhuri, K. (1992) Role of nontuberculuos infection in immunization against tuberculosis. Indian Journal of Tuberculosis, 39. pp. 165-170.
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Whether Mycobacterium aviumintracellulare (MAI), the most common of all nontuberculous mycobacteria isolated from south India interferes with protective effect of Bacillus Calmette-Guerin (BCG) was studied in albino guinea pigs. Groups of animals were given combinations of treatment with BCG, MAI or placebo and then challenged with high/low virulent strains of M.tuberculosis. Both oral and intradermal routes were tested for infecting guinea pigs with MAI. The extent of haematogenous dissemination of tubercle bacilli revealed that oral sensitization with MAI adversely influenced the protective effect of BCG vaccine against high virulent challenge. However, intradermal route of immunization with MAI did not interfere with the protective immunity induced by BCG in guinea pigs, challenged with high/low virulent isolates of M. tuberculosis.
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