Role of nontuberculuos infection in immunization against tuberculosis

Challu, Vijay K.; Chandrasekaran, Sujatha; Sreenivas, T.R.; Chauhan, M.M.; Jones, B.; Rajalakshmi, R.; Mahadev, B.; Balasangameshwara, V.H. and Chaudhuri, K. (1992) Role of nontuberculuos infection in immunization against tuberculosis. Indian Journal of Tuberculosis, 39. pp. 165-170.

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Abstract

Whether Mycobacterium aviumintracellulare (MAI), the most common of all nontuberculous mycobacteria isolated from south India interferes with protective effect of Bacillus Calmette-Guerin (BCG) was studied in albino guinea pigs. Groups of animals were given combinations of treatment with BCG, MAI or placebo and then challenged with high/low virulent strains of M.tuberculosis. Both oral and intradermal routes were tested for infecting guinea pigs with MAI. The extent of haematogenous dissemination of tubercle bacilli revealed that oral sensitization with MAI adversely influenced the protective effect of BCG vaccine against high virulent challenge. However, intradermal route of immunization with MAI did not interfere with the protective immunity induced by BCG in guinea pigs, challenged with high/low virulent isolates of M. tuberculosis.

EPrint Type:Article
Additional Information:Paper presented at the 46th National Conference on Tuberculosis and Chest Diseases, New Delhi : 22-24 November, 1991.
Uncontrolled Keywords:Mycobacterium aviumintracellulare, Nontuberculous Infection, Immunization, Tuberculosis, Guinea pigs
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
-Institutional Repositories > National Tuberculosis Institute
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections
Investigative Techniques > Models, Animal
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
Animal Diseases > Bird Diseases > Tuberculosis, Avian
Therapeutics > Biological Therapy > Immunotherapy > Immunization
-Journal Repositories > Indian Journal of Tuberculosis
Immunologic and Biological Factors > Biological Products > Vaccines > Bacterial Vaccines > Tuberculosis Vaccines > BCG Vaccine
ID Code:636
Deposited By:Librarian Sudha S Murthy
Deposited On:09 August 2005

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