Results of treatment with a short course chemotherapy regimen used field conditions in District Tuberculosis Programme
Chaudhuri, K.; Jagota, P. and Parimala, N. (1993) Results of treatment with a short course chemotherapy regimen used field conditions in District Tuberculosis Programme. Indian Journal of Tuberculosis, 40. pp. 83-89.
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The treatment results of an unsupervised Short Course Chemotherapy (SCC) regimen used under conditions of District Tuberculosis Programme (DTP) are presented. The District Tuberculosis Centre (DTC) Kolar and six of its peripheral health institutions (PHI) formed the study area. No extra efforts except ensuring of adequate availability of drugs at the participating centers were made to obtain patients’ compliance. In all, 584 smear positive tuberculosis patients were diagnosed during the study period but 28.3% of the patients could not be initiated on treatment with the chosen self-administered SCC regimen- 2EHRZ/6TH (EH). Of the 382 put on treatment, only 33.2% completed over 75% drug collections in both intensive and continuation phases. The pattern of treatment compliance did not vary with the place of treatment, i.e. DTC & PHI. Irrespective of treatment compliance, nearly 72-77% of the patients attained smear negative status at the end of the period of treatment, there being no difference between PHI and DTC. However, deaths were higher in the PHI patients. This could be attributed to a significantly higher proportion of aged patients taking treatment at PHI than at DTC. Patients with drug sensitive bacilli had a higher rate of culture negativity (70%) as compared to those with drug resistant bacilli (48%). It was concluded that unsupervised SCC could give encouraging results in a DTP setting provided adequate drug supply was ensured.
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